BIOPHYISCAL AND BIOCHEMICAL PROCESSES ON SUBSTRATES:

MICROARRAYS AND MEMBRANES STUDIED BY LABEL-FREE OPTICAL MICROSCOPES

"A microfluidic strategy to capture antigen-specfic high affinity B cells," with Ahmed M. Alhassen, Venktesh S. Shirure, Jean Luo, Bryan B. Nguyen, Zachary A. Rollins, Bhupinder S. Shergill, Nicole Baumgarth, and Steven George. Advanced NanoBiomed Research. (in press, 2023).

"Detection speed optimization of OI-RD microscope for ultra-high throughput screening (PDF)," with Hang Zhang, Mengjing Xu, Haofeing Li, Xiaohan Mai, Jiawei Sun, Lan Mi, Jiong Ma, and Yiyan Fei. Biomedical Optics Express 14, 1848 (2023).

"Characterization and clinical validation of patient-specific threedimensional printed tissue-equivalent bolus for radiotherapy of head and neck malignancies involving skin (PDF)," with Brandon A. Dyer, Daniel Hernandez, and Shyam S. Rao et al. Physica Medica 77, 138 (2020).

"Label-free Microarray-based Binding Affinity Constant Measurement with Modified Fluidic Arrangement (PDF)," with Junwei Hu, Ru Chen, Chenggang Zhu, Bilin Ge, Lan Mi, Jiong Ma, Caiqin Han, Hao Chen, Yiyan Fei, Biochip Journal 12, 11 (2018).

"Fast focal length correction in prism-coupled total internal reflection scanning imager using electronically tunable lens (PDF)," with Chenggang Zhu, Bilin Ge, Ru Chen, Lan Mi, Jiong Ma, Xu Wang, Fengyun Zheng, Yiyan Fei, Sensors 18, 524 (2018).

"Detecting Signals with Direct Fast Fourier Transform for Microarray Data Collection (PDF)," with Ru Chen, Chenggang Zhu, Bilin Ge, Yung-shin Sun, Lan Mi, Jiong Ma, Xu Wang, and Yiyan Fei, IEEE Photonics Technology Letters 2, 2211 - 2214 (2017).

"Single Amino Acid Substitution in the Vicinity of a Receptor-Binding Domain Changes Protein-Peptide Binding Affinity (PDF)," with Galina Malovichko, ACS OMEGA 2, 5445 - 5452 (2017).

"Calibration of oblique-incidence reflectivity difference (OI-RD) for label-free detection of molecular layer (PDF)," with Chenggang Zhu, Ru Chen, Yuzhangyang Zhu, Xu Wang, Lan Mi, Fengyun Zheng, and Yiyan Fei, Applied Optics 55, 9459 (2016).

"Characterization of protein expression levels with label-free detected reverse phase protein arrays (PDF)," with Xuexue Guo, Yihong Deng, Chenggang Zhu, Junlong Cai, James P. Landry, Fengyun Zheng, Xunjia Cheng, and Yiyan Fei, Analyt. Biochem. 509, 67-72 (2016).

"Developing an efficient and general strategy for immobilization of small molecules onto microarrays using isocyanate chemistry (PDF)," with Chenggang Zhu, James P. Landry, Zhaomeng Cui, Quanfu Li, Yongjun Dang, Lan Mi, Fengyun Zheng and Yiyan Fei. Sensors 16, 378 (2016).

"Label-Free Real-Time Monitoring of Reactions Between Internalin A and Its Antibody by an Oblique-Incidence Reflectivity-Difference Method (PDF)," with Xu Wang, Galina Malovichko, Marcelo Mendon, Fabricio Rochedo Concei, and Jose AG Aleixo, Journal of Optical Society of Korea 20, 165 (2016).

"Characterization of receptor binding profiles of influenza A viruses using an ellipsometry based label-free glycan microarray assay platform (PDF)," with Yiyan Fei, Yung-Shin Sun, James P. Landry, Yanhong Li, Hai Yu, Kam Lau, Zeng Luo, Nicole Baumgarth, and Xi Chen, Biomolecules 5, 1480 - 1498 (2015).

"Characterization of Bovine Serum Albumin Blocking Efficiency on Epoxy-Functionalized Substrates for Microarray Applications (PDF)," with Yung-shin Sun, Journal of Laboratory Automation. (2015): 2211068215586977.

"High-throughput Dose-Response Measurement Using a Label-Free Microarray-in-Microplate Assay Platform (PDF)," with James P. Landry, Galina Malovichko, Anal. Chem. 87, 5640-5648 (2015).

"Kinetic Analysis of Biomolecular Interactions using Label-Free Biosensors (PDF)," with Yung-shin Sun, Instrumentation Science & Technology 43, 255 - 267 (2015).

"Measuring Affinity Constants of 1,450 Monoclonal Antibodies to Peptide Targets with a Microarray-based Label-Free Assay Platform (PDF)," with James P. Landry, Yaohuang Ke, and Guo-Liang Yu, Journal of Immunological Methods 417, 86-96 (2015).

"Real-Time, Label-Free Detection of Biomolecular Interactions in Sandwich Assays by the Oblique-Incidence Reflectivity Difference Technique (PDF)," with Yung-shin Sun, Sensors 14, 23320 (2014).

"Determination of Bovine Serum Albumin Conjugated Drugs by Immobilization as Microarrays and Oblique-Incidence Reflectivity Difference Microscopy (PDF), " with Yung-shin Sun and Kit S. Lam, Instrumentation Science & Technology 42, 475 - 485 (2014).

"Generating Encoded Compound Libraries for Fabricating Microarrays as a High-throughput Protein Ligand Discovery Platform (PDF)," with Yung-shin Sun, Yiyan Fei, Juntao Luo, Seth Davis, James P. Landry, Kit S. Lam, Synthetic Communications 44, 987-1001 (2014).

"Ellipsometry-based biosensor for label-free detection of biomolecular interactions in microarray format (PDF)," with Yung-shin Sun, Sensors & Materials 25, 673 - 688 (2013).

"An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support (PDF)," with Yiyan Fei, James P. Landry, Yanhong Li, Hai Yu, Kam Lau, Shengshu Huang, Harshal A. Chokhawala and Xi Chen, Rev. Sci. Instrum. 84, 114102 (2013).

"Detection of Formation and Disintegration of Micelles by Oblique-Incidence Reflectivity Difference Microascopy (PDF)," with Yung-shin Sun, Juntao Luo, Kit S. Lam, Instrumentation Science & Technology 41, 545 - 555 (2013).

"An oblique-incidence reflectivity difference study of the dependence of probe-target reaction constants on surface target density using streptavidin-biotin reactions as a model (PDF)," with Yung-shin Sun, James P. Landry, and Yiyan Fei, Instrumentation Science & Technology 41, 535 - 544 (2013).

"Discovering Small Molecule Ligands of VEGF that Block VEGF-KDR Binding Using Label-Free Microarray-based Assays (PDF)," with James P. Landry, Yiyan Fei, Yaohuang Ke, Guoliang Yu, and Pierre Lee, Assay and Drug Development Technologies 11 (June), 326 - 332 (2013).

"Kinetic identification of protein ligands in a 51,200 small-molecule library using microarrays and a label-free ellipsometric scanner (PDF)," with James P. Landry, Andrew P. Proudian, Galina Malovichko, SPIE 8587 (2013).

"Simultaneous Measurement of 10,000 Protein-Ligand Affinity Constants Using Microarray-based Kinetic Constant Assays (PDF)," with James P. Landry and Yiyan Fei, Assay and Drug Development Technologies 10, 250 - 259 (2012).

"High Throughput, Label-free Screening Small Molecule Compound Libraries for Protein-Ligands using Combination of Small Molecule Microarrays and a Special Ellipsometry-based Optical Scanner (PDF)," with James P. Landry and Yiyan Fei, International Drug Discovery, December/January, 8-13 (2012).

"Fluorescent Labeling Agents Change Binding Profiles of Glycan-Binding Proteins (PDF)," with Yiyan Fei, Yung-Shin Sun, Yanhong Li, Kam Lau, Hai Yu, Harshal A. Chokhawala, Shengshu Huang, James P. Landry, and Xi Chen, Mol. BioSys. 7, 3343 - 3352 (2011).

"Real-time, label-free analysis reveals novel low-affinity binding to blood group antigens by Helicobacter pylori (PDF)," with Y.Y. Fei, A. Schmidt, G. Bylund, D.X. Johansson, S. Henriksson, C. Lebrilla, J.V. Solnick, T. Boren, Anal. Chem. 83, 6336 - 6341 (2011).

"Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy (PDF)," with Kai-Yin Lo, Yung-Shin Sun, James P. Landry, Wenbin Deng, BioTechniques 50, 381 - 388 (2011).

"Screening Small Molecule Compound Microarrays for Protein Ligands without Fluorescence Labeling with a High-Throughput Scanning Microscope (PDF)," with Y.Y. Fei, J.P. Landry, Y.S. Sun, J.T. Luo, X.B. Wang, C.Y. Wu, and K.S. Lam, J. Biomed. Opt.15, 016018 (2010).

"Label-free screening small-molecule compound libraries for protein ligands using a high-throughput optical scanning microscope," with Y.Y. Fei, J.P. Landry, Y.S. Sun, J.T. Luo, X.B. Wang, C.Y. Wu, and K.S. Lam, Proc. SPIE 7182, 7182Q2 (2009).

"Label-free optical detection of small-molecule compound microarray immobilized on solid support using macromolecular scaffolds and subsequent protein binding reactions," with Y.S. Sun, J.P. Landry, Y.Y. Fei, J.T. Luo, X.B. Wang, and K.S. Lam, Proc. SPIE 7182, 71820P (2009).

"Macromolecular scaffolds for immobilizing small molecule microarrays in label-free detection of protein-ligand interactions on solid support (PDF)," with Y.S. Sun, J.P. Landry, Y.Y. Fei, J.T. Luo, X.B. Wang, and K.S. Lam, Anal. Chem. 81, 5373-5380 (2009).

"Effect of fluorescently labelling protein probes on kinetics of protein-ligand reactions (PDF)," with Y.S. Sun, J.P. Landry, Y.Y. Fei, J.T. Luo, X.B. Wang, and K.S. Lam, Langmuir 24, 13399-13405 (2008).

"A study of protein reactions with surface-bound molecular targets using oblqiue-incidence reflectivity difference microscope (PDF)," with J.P. Landry, Y.S. Sun, and X.W. Guo, Appl. Opt. 47, 3275-3288 (2008).

"A novel high-throughput scanning microscope for label-free detection of protein and small-molecule chemical microarrays (PDF)," with Y.Y. Fei, J.P. Landry, Y.S. Sun, J.T. Luo, X.B. Wang, K.S. Lam, Rev. Sci. Instrum. 79, 013708 (2008).

"Oblique-Incidence Reflectivity Difference Microscope for Label-Free High-Throughput Detection of Biochemical Reactions in Microarray Format (PDF)," with J.P. Landry, Y.S. Sun, J.P. Gregg, and K.S. Lam, Appl. Opt. 46, 1890 (2007).

"Biophotonic studies on lipid membranes using oblique-incidence reflectivity difference (OI-RD) ellipsometry," with R. Masina, A.N. Parikh, R. Bruch, and J.P. Landry, Proc. SPIE. 6095, 153-161 (2006).

"Applications of Oblique-Incidence Reflectivity Difference Method in Primary Study of Protein Biomolecules (PDF)," with H.Y. Zhang, R.Q. Liang, K.J. Jin, H.B. Lu, X.D. Zhu, Y.L. Zhou, K.C. Ruan, and G.Z. Yang, Chin. Phys. Lett. 23, 1032 (2006).

"Incidence-angle dependence of optical reflectivity difference from an ultrathin film on solid surface (PDF)," with J.P. Landry, J.J. Gray, and M.K. O'Toole, Opt. Lett. 31, 531-533 (2006).

"Comparison of two optical techniques for label-free detection of biomolecular microarrays on solids (PDF)," Opt. Commun. 259, 751-753 (2006).

"Detection of biomolecular microarrays without fluorescent-labeling agents (PDF)," with J.P. Landry, J.P. Gregg, and X.W. Guo, Proc. of SPIE. 5328, 121 (2004).

"Label-free detection of microarrays of biomolecules using oblique-incidence reflectivity difference microscopy (PDF)," with J.P. Landry, J. Gregg, Opt. Lett.. 29, 581 (2004).

"Oblique-Incidence Reflectivity Difference and Fluorescence Imaging of Oligonucleotide and IgG Protein Microarrays," with J. P. Landry, J. Gregg, X.W. Guo, Mat. Res. Soc. Proc. 773, N5.5.1 (2003) (PDF).